Welcome to the RNA-processing and therapeutics lab!
We are located in the Neurosciences Area of Biodonostia Health Research Institute:
Biodonostia HRI (http://www.biodonostia.org/en/) is a national and international centre of reference in the field of health research, giving priority to promoting translational research. The institute is arranged in 7 subject areas that bring together around 350 researchers.
The lab is located in the beautiful city of San Sebastian (Spain), placed amongst the top 200 science cities in the world, according to Nature (https://www.natureindex.com/supplements/nature-index-2018-science-cities/tables/overall)
The group has two research priorities:
To study non-coding genetic mutations and misregulation of RNA-processing events in human neurological disorders.
To develop RNA-targeting CRISPR-Cas systems as a personalised therapeutic strategy for RNA-processing disorders.
We have received funding to develop our research ideas:
- 'Ramon y Cajal' and 'Ikerbasque Fellow' research contracts, starting in August 2020, awarded to Lorea Blazquez.
- A health research project from Instituto de Salud Carlos III (ISCIII), PI19/00468, to develop CRISPR-dCas13 system as a general technology platform to deliver antisense RNAs and correct specific RNA-processing events in neurodegenerative diseases.