RNA-processing and therapeutics lab

Welcome to the RNA-processing and therapeutics lab!

We are located in the Neurosciences Area of Biodonostia Health Research Institute:

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• Biodonostia HRI (http://www.biodonostia.org/en/) is a national and international centre of reference in the field of health research, giving priority to promoting translational research. The institute is arranged in 7 subject areas that bring together around 350 researchers.

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• The lab is located in the beautiful city of San Sebastian (Spain), placed amongst the top 200 science cities in the world, according to Nature (https://www.natureindex.com/supplements/nature-index-2018-science-cities/tables/overall)

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The group has two research priorities:

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• To study non-coding genetic mutations and misregulation of RNA-processing events in human neurological disorders.

• To develop RNA-targeting CRISPR-Cas systems as a personalised therapeutic strategy for RNA-processing disorders.

We have received funding to develop our research ideas:

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- 'Ramon y Cajal' and 'Ikerbasque Fellow' research contracts, starting in August 2020, awarded to Lorea Blazquez. 

- A health research project from Instituto de Salud Carlos III (ISCIII), PI19/00468, to develop CRISPR-dCas13 system as a general technology platform to deliver antisense RNAs and correct specific RNA-processing events in neurodegenerative diseases.